
•	Overview
•	Intravital^2P
•	Two-Photon iMIC
•	Applications
•	Flexibility
•	3D FRAP/uncaging and 2PPM
•	The two-photon advantage

Hotline

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2 Photon iMIC Data Sheet (496 KB)

TILL Two-Photon iMIC

Two-Photon iMIC inverted platform for imaging large samples in vivo

The Two-Photon iMIC

Combining the performance of the Intravital2P with the compact design and flexibility of the iMIC, the Two-Photon iMIC is our compact solution for microscopy in thick tissues.

Visualize cells in thick samples without mechanical sectioning

Observations of cells in intact tissues are an important new discipline that aids existing and novel research areas such as...

Embryology / developmental biology
Tumor / cancer research...

Click for a better view at this image stack that shows how you con scan through a whole anchovy retina without mechanical slicing!

The modularity of the iMIC platform allows tailoring your personal two-photon microscope

The iMIC Digital Microscope series is a fully motorized digital imaging platform that is freely configurable to integrate microscopy techniques from transmitted light to spinning disc confocal imaging. Modalities like FRET/FRAP/TIRF can be added as needed. Since November 2010, the iMIC can also integrate two-photon laser scanning microscopy. Two-photon fluorescence excitation is a very rich technique, allowing to image any kind of fluorescent label, or intrinsic ("auto-") fluorescence, or second/third harmonic generation...

Time lapse movie showing the transmitter-evoked dissociation and re-association of a G-protein complex. Recorded with the two-photon polarisation microscopy (2PPM) upgrade attached to a Two-Photon iMIC.

It is easy to combine imaging modalities in the Two-Photon iMIC: from wide-field flourescence to multi-channel two-photon microscopy

The iMIC architecture with stacked layers that each have three identical optical ports lends itself to incorporating any number of optical components. In the dual-detector model with three layers, only 5 of 9 ports are used (for epi-illumination condenser, camera, laser scanner, and the two detector modules). Each of the four open ports can be used...